Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2
نویسندگان
چکیده
منابع مشابه
Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.
OBJECTIVES Peroxynitrite (ONOO(-)) mediates in part both ischemia-reperfusion and pro-inflammatory cytokine-induced injury to the heart. As oxidants like ONOO(-) are known to activate matrix metalloproteinases (MMPs), we examined whether they play a role in the detrimental action of ONOO(-) in isolated perfused rat hearts. METHODS Hearts were isolated from Sprague-Dawley rats and perfused ret...
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In the fall of 2006 I joined the Department of Pharmacology, University of Alberta as a PhD graduate student under the supervision of Dr. Richard Schulz. The Schulz lab studies ischemic and inflammatory heart diseases and investigates the role of specific molecules contributing to oxidative stress injury of the heart. Being in the first laboratory to discover that matrix metalloproteinase (MMP)...
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BACKGROUND Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and diastolic function. Loss of titin in ischemic hearts has been reported, but the mechanism of titin degradation is not well understood. Matrix metalloproteinase-2 (MMP-2) is localized to the cardiac sarcomere and, on activation...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2002
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(01)00445-x